Book a trip from Manila to San Francisco with Cathay Pacific , fares from USD646

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Fly Cathay Pacific from Manila (MNL) to San Francisco (SFO). Enjoy award-winning service, entertainment, and an enhanced menu for Premium Economy and Business Class during your flight. Book direct to secure our best fare and join as a Cathay Pacific Member to earn Status Points or Miles.

Deals on Manila (MNL) to San Francisco (SFO) flights

Book flights to San Francisco SFO

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Book flights to San Francisco SFO
From
To
Fare Type
Dates
Price
Manila (MNL)San Francisco (SFO)Round-trip
/
Economy
24/11/2025 - 09/12/2025

From

USD646

Seen 1 day ago

Manila (MNL)San Francisco (SFO)Round-trip
/
Economy
10/02/2026 - 24/02/2026

From

USD646

Seen 1 day ago

Manila (MNL)San Francisco (SFO)Round-trip
/
Economy
04/12/2025 - 06/01/2026

From

USD646

Seen 1 day ago

Manila (MNL)San Francisco (SFO)Round-trip
/
Economy
21/01/2026 - 28/01/2026

From

USD646

Seen 1 day ago

Manila (MNL)San Francisco (SFO)Round-trip
/
Economy
06/11/2025 - 15/11/2025

From

USD646

Seen 1 day ago

Book Business Class flights to San Francisco - selected offers

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Flights from Manila (MNL) to San Francisco (SFO)

Flight route information

Cathay Pacific offers daily flights to San Francisco International Airport (SFO) from Manila Ninoy Aquino Airport (MNL) with a layover in Hong Kong. The journey, including the layover, takes around 16 hours 15 minutes and brings you to Terminal I in San Francisco.

Upon your arrival in San Francisco

Taxis and Ubers are readily available just outside the San Francisco Airport terminal, and can get you to the city centre in 35 minutes. Alternatively, San Francisco’s BART train service takes 30 minutes to get downtown. There are also local buses and car rental services available.

A brief introduction to San Francisco

Known for its rolling hills and eclectic architecture, the coastal Californian city of San Francisco is as quintessentially quirky as it is perfectly picturesque.

Take a ride through San Francisco’s Victorian history in one of the city’s iconic cable cars. During your ride, you will see famous architecture such as the Painted Ladies, the intricately designed houses of Haight-Ashbury, and the winding, postcard-worthy Lombard Street.

With the most restaurants and farmers’ markets per capita in North America, San Francisco is also a paradise for foodies. Be sure to visit Pier 39 at Fisherman’s Wharf, where you can dine while overlooking California sea lions relaxing in the sun. While there, look out across the bay and you’ll see the notorious island of Alcatraz – a former prison that was considered escape-proof due to the powerful water currents of San Francisco Bay.

From the piers, travellers can take a light hike or bike ride on the Coastal Trail to the Golden Gate National Recreation Area. Here, you can marvel at the Pacific Ocean and get an enviable view of the iconic Golden Gate Bridge.


Flying to San Francisco with Cathay Pacific

Book your Manila to San Francisco flight and experience Cathay Pacific’s world class hospitality and service courtesy of our attentive crew. You can also enjoy a wide selection of Hollywood films and complete TV box sets on our inflight content library, as well as games, podcasts, and more.

Inflight experiences

Fly from Manila to San Francisco with Cathay Pacific and experience utmost comfort. You’ll also be served dishes from our curated dining menus during your flight, including a selection of healthy meals that feature seasonal ingredients. To accompany our inflight dining menu, we have an award-winning selection of wines that you can pair with your meal.

 

All fares displayed include taxes and carrier-imposed surcharges. All fares, government taxes and fees, and surcharges are subject to change at any time. For ticket cancellations, where applicable, the Hong Kong Passenger Security Charge, the Hong Kong Air Passenger Departure Tax, and the Hong Kong International Airport Construction Fee will be refunded without any administration fees.